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Figure 3.4 Protein translation
Modified from National Human Genome Research Institute
The three-nucleotide sequence elements on mRNA that code for individual
amino acids are called codons. These are matched by anti-codons on tRNA
to ensure that the appropriate amino acid as aligned with a given mRNA
sequence. The 64 possible combinations of A, C, G, and T at each codon
code for only 20 different amino acids. This redundancy in the genetic
code, permitting multiple codons to specify common amino acids, is
considered a form of protection against DNA mutations and has
applications
in identifying foreign DNA from sources such as viruses which use
different
'dialects' of the genetic code.
The chemical characteristics of the amino acids in a protein chain cause
it to fold into a defined structure. The structure of a protein
determines
its function. Because the DNA sequence of a gene, through an mRNA
intermediate, dictates the sequence of amino acids in a protein, and the
sequence of amino acids in a protein determines its structure, one can
deduce a protein sequence, and potentially (but not yet) its structure
and function, from the gene sequence encoding it.
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