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Table 14.1 Biotechnology business models
General modelsCharacterstics
Product developmentHigh risk, high reward. Requires supporting financing environment.
No research, development only (NRDO) Reduced risk, high reward. Dependent upon ability to acquire drug leads; lack of internal R&D challenges decision making and long-term growth.
Reagents and tools Low risk, low reward. Subject to commoditization and obsolescence; success is predicated on dominating markets and niches.
Special cases Characteristics
Hybrid product / platform Reduces risk of product development, allows a company to prove technologies and generate revenues. Potentially distracting to management and R&D efforts. May be used to distract investors to failing core activities.
Virtual company Effective for bootstrapping start-ups, difficult and expensive to manage at later stages.
Non-profit Requires charitable donations and ability to license viable abandoned leads from incumbents.
Repositioning Similar to NRDO. Requires ability to license and patent existing drugs for new uses.

Maximizing Multiples

The ultimate goal of biotechnology companies is to use molecular biology techniques to produce novel products worthy of a price that is greater than the investment in developing those products. While it was once possible for a nascent biotechnology company to develop into a fully integrated research, development, and commercialization enterprise, market dynamics have made it much more cost-effective for companies to specialize in discrete elements of this pathway. In order to be profitable, it is essential


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