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failure are mismanagement and undercapitalization. Accordingly, biotechnology companies should secure able investors and ensure that milestones are consistently met.

Selecting Opportunities and Attracting Funding

In order to attract investors and build a biotechnology company, a commercial idea must exist with the potential to generate revenues. Innovative technologies and ambitious goals may attract press attention and early investors, but continued success requires profitable commercial execution.
Consider the case of Genentech. The company quickly completed proof-of-principle research to demonstrate the power of their revolutionary bacterial protein-expression system and signed a development contract to produce human insulin. After developing a method to produce human insulin in bacteria, Genentech applied the same basic techniques and secured external funding to produce human growth hormone. While Genentech has since diversified into additional research areas, their initial plan focused on a single, patent protected, new technology with multiple defined commercial possibilities.
The primary objective of a biotechnology start-up is to secure a competitive advantage, followed by assembling a management team and obtaining funding. At some stage in this process, a business plan will have to be formulated.

Commercial Strategy

It is not the planning that is important; it is the planning that makes you able to change it.
Dwight D. Eisenhower

Business plans often change as a company develops. One of the objectives of formulating a business plan is to determine the best course for implementation. While the initial business plan may be a rudimentary outline of a commercial idea, investigations into the feasibility, applications, and market potential of the idea can lead to modifications, resulting in a relatively stable concept that justifies the formation of a company. If an idea has a small market, requires an extremely large investment, or can only be used as part of a third party's patented process, then it may be better to sell


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